Expression, Localization, and Regulation of the Sodium Bicarbonate Cotransporter NBCe1 in the Thyroid
| Autor: | Jacques Emile Dumont, Xavier De Deken, Myrna Virreira, Renaud Beauwens, Michal Svoboda, Françoise Miot, Sami Djerbib, Jacqueline Van Sande, Claude Massart, Alain Boom, Ling Jin |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
endocrine system SLC4A4 Cytoplasm Thyroid Hormones endocrine system diseases Endocrinology Diabetes and Metabolism Thyroid Gland Thyrotropin Stimulation Sodium-Bicarbonate Cotransporter thyroid Mice Endocrinology stomatognathic system Internal medicine medicine Animals Humans NBCe1 variants Rats Wistar biology Chemistry TSH Sodium-Bicarbonate Symporters Thyroid Cell Membrane Compartment (chemistry) Endocrinologie Rats medicine.anatomical_structure Gene Expression Regulation Génétique cytogénétique Thyroid hormones biology.protein Female NBC1 hormones hormone substitutes and hormone antagonists |
| Zdroj: | Thyroid |
| ISSN: | 1557-9077 |
| Popis: | The intrafollicular space of thyroid follicles is the storage compartment for thyroid hormones. Its pH has been established at around 7.6 at least after thyrotropin (TSH) stimulation. This alkaline intrafollicular pH is thought to be critical for iodide coupling to thyroglobulin and internalization of iodinated thyroglobulin. At least in mice, this alkalinization requires the expression of pendrin (Slc26a4) within the apical membrane, and a lack of pendrin results in acidic follicular lumen pH. Yet, the mechanism importing HCO3- into the cytoplasm is unknown. This study investigated whether the rather ubiquitous sodium bicarbonate cotransporter NBCe1 (SLC4A4) might play this role. It also examined which variant was expressed and where it was localized in both rat and human thyroid tissue. Lastly, the dependence of its expression on TSH was studied. SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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