Studies of pancreatic nodule induction and DNA damage by D-azaserine☆
| Autor: | Elna T. Kuhlmann, Joanne Zurlo, Daniel S. Longnecker, David A. Cooney, Thomas J. Curphey |
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| Rok vydání: | 1981 |
| Předmět: |
Cancer Research
medicine.medical_specialty DNA damage Biology In vivo Internal medicine medicine Acinar cell Animals Azaserine Pancreas Stereoisomerism Nodule (medicine) DNA Metabolism In vitro Rats Endocrinology medicine.anatomical_structure Liver Oncology Rats Inbred Lew Carcinogens medicine.symptom medicine.drug |
| Zdroj: | Cancer Letters. 12:75-80 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/0304-3835(81)90040-9 |
| Popis: | The ability of the D-isomer of azaserine to induce atypical acinar cell nodules (AACN) in pancreas and to cause DNA damage in pancreas and liver was evaluated. Rats were injected with equivalent doses of D- or L-azaserine and numbers of AACN were counted after 4 months. DNA damage in pancreas and liver of rats treated in vivo, and in pancreatic acinar cells treated in vitro with D- or L-azaserine was determined by alkaline elution. Results show that D-azaserine does not significantly induced AACN in pancreas, nor does it cause extensive DNA damage in comparison with L-azaserine, suggesting that the differential effect of the 2 isomers is related to stereospecificity in either transport or metabolism. |
| Databáze: | OpenAIRE |
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