Influence of age on the correlations of hematological and biochemical variables with the stability of erythrocyte membrane in relation to sodium dodecyl sulfate
| Autor: | Leticia Ramos de Arvelos, Mariana Vaini de Freitas, Mario da Silva Garrote-Filho, Ana Flávia M. Gonçalves e Oliveira, Liandra Freitas Márquez-Bernardes, Paulo César A. de Souza, Rita de Cássia Mascarenhas Netto, Lara Ferreira Paraiso, Nilson Penha-Silva, Morun Bernardino Neto |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose Erythrocyte Indices medicine.medical_specialty Aging Lysis Erythrocytes Population Serum albumin Hemolysis chemistry.chemical_compound Hemoglobins Surface-Active Agents Young Adult Internal medicine Linear regression medicine Humans Sodium dodecyl sulfate education Serum Albumin Aged Aged 80 and over education.field_of_study biology Dose-Response Relationship Drug Erythrocyte Membrane Albumin Age Factors Sodium Dodecyl Sulfate Red blood cell distribution width Hematology Middle Aged Lipids Endocrinology Biochemistry chemistry Hematocrit Spectrophotometry Multivariate Analysis biology.protein Linear Models Female Hemoglobin |
| Zdroj: | Hematology (Amsterdam, Netherlands). 19(7) |
| ISSN: | 1607-8454 |
| Popis: | ObjectivesTo evaluate the influence of age on the relationships between biochemical and hematological variables and stability of erythrocyte membrane in relation to the sodium dodecyl sulfate (SDS) in population of 105 female volunteers between 20 and 90 years.MethodsThe stability of RBC membrane was determined by non-linear regression of the dependency of the absorbance of hemoglobin released as a function of SDS concentration, represented by the half-transition point of the curve (D50) and the variation in the concentration of the detergent to promote lysis (dD).ResultsThere was an age-dependent increase in the membrane stability in relation to SDS. Analyses by multiple linear regression showed that this stability increase is significantly related to the hematological variable red cell distribution width (RDW) and the biochemical variables blood albumin and cholesterol.DiscussionThe positive association between erythrocyte stability and RDW may reflect one possible mechanism involved in the clin... |
| Databáze: | OpenAIRE |
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