Formation of the head organizer in hydra involves the canonical Wnt pathway
| Autor: | Hans R. Bode, Mariya Broun, Lydia Gee, Beate Reinhardt |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Beta-catenin
Indoles Head (linguistics) Hydra Glycogen Synthase Kinase 3 Animals Glycogen synthase Molecular Biology GSK3B beta Catenin Cell Nucleus Glycogen Synthase Kinase 3 beta biology Cell Cycle Cell Membrane Wnt signaling pathway Intracellular Signaling Peptides and Proteins Benzazepines Cell biology Transplantation Wnt Proteins Cytoskeletal Proteins biology.protein Trans-Activators Intercellular Signaling Peptides and Proteins Hypostome Lernaean Hydra Head Developmental Biology Signal Transduction |
| Zdroj: | Development (Cambridge, England). 132(12) |
| ISSN: | 0950-1991 |
| Popis: | Stabilization of β-catenin by inhibiting the activity of glycogen synthase kinase-3β has been shown to initiate axis formation or axial patterning processes in many bilaterians. In hydra, the head organizer is located in the hypostome, the apical portion of the head. Treatment of hydra with alsterpaullone, a specific inhibitor of glycogen synthase kinase-3β,results in the body column acquiring characteristics of the head organizer, as measured by transplantation experiments, and by the expression of genes associated with the head organizer. Hence, the role of the canonical Wnt pathway for the initiation of axis formation was established early in metazoan evolution. |
| Databáze: | OpenAIRE |
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