Glomerular filtration rate can be accurately predicted using lean mass measured by dual-energy X-ray absorptiometry
| Autor: | Timothy P. Taylor, M Zakarea Shrayyef, Crystal A. Gadegbeku, Wei Wang, DeAnna Cheek, Florence N. Hutchison |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Correlation coefficient Renal function Iothalamate Clearance Sensitivity and Specificity Severity of Illness Index Body Mass Index Cohort Studies chemistry.chemical_compound Absorptiometry Photon Predictive Value of Tests Internal medicine medicine Humans Dual-energy X-ray absorptiometry Probability 24 h urine Transplantation Creatinine medicine.diagnostic_test business.industry Middle Aged medicine.disease Endocrinology chemistry Nephrology Body Composition Lean body mass Female Kidney Diseases business Nuclear medicine Glomerular Filtration Rate Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation. 21:84-87 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfi102 |
| Popis: | Background. Accurate assessment of renal function is important in the management of patients with kidney disease yet is often difficult to obtain. Formulae, designed for clinical use, have been developed to predict glomerular filtration rate (GFR) utilizing serum creatinine (S cr ). Additional parameters are included in these formulae to account for variations in S cr due to differences in total body lean mass in kg (LM). Therefore, the purpose of this study was to derive a simple formula to predict GFR based on S cr and direct quantification of LM. Methods. Ten subjects with a wide range of renal function had GFRs determined by [ 125 I]iothalamate clearance and LM determined by dual-energy X-ray absorptiometry as well as fasting measurements of S cr , serum and 24 h urine urea nitrogen, and albumin. Results. The following formula was derived using LM (kg) and S cr (mg/dl): predicted GFR=(2.4 x LM)-(0.75 x LM x S cr ). The correlation coefficient for this formula was 0.97, when compared with [ 125 I]iothalamate clearances, and similar to the MDRD formulae (R=0.87-0.95). Conclusion. Although further validation is necessary, these findings suggest that total body non-invasive measurement of LM along with S cr can be used to accurately predict GFR. |
| Databáze: | OpenAIRE |
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