Adverse childhood experience and rheumatic diseases
| Autor: | Angelica Beate Winter Boldt, Renato Nisihara, Thelma L. Skare, Heloisa de Alencar Antico, Ana Paula Lopes Luiz |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Scleroderma Fight-or-flight response Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Rheumatology Risk Factors Internal medicine Surveys and Questionnaires Spondylarthritis medicine Humans Lupus Erythematosus Systemic skin and connective tissue diseases Adverse Childhood Experiences Adverse effect Childhood abuse 030203 arthritis & rheumatology Scleroderma Systemic business.industry Rheumatic disease General Medicine Middle Aged medicine.disease Adult Survivors of Child Adverse Events Rheumatoid arthritis Female business 030217 neurology & neurosurgery |
| Zdroj: | Clinical rheumatology. 37(10) |
| ISSN: | 1434-9949 |
| Popis: | It has been suggested that the adaptive stress response may be disrupted by life adverse events such as childhood maltreatment. To investigate if the number of adverse childhood experiences (ACEs) increases susceptibility to systemic lupus erythematosus (SLE), spondyloarthritis (SpA), scleroderma (SSc), and rheumatoid arthritis (RA), we interviewed 315 patients with rheumatic disease (100 SLE; 40 SSc; 60 SpA; 115 RA) and 272 controls, using questions of the ACEs study questionnaire validated to ask about experiences of childhood abuse, negligence, domestic violence, and household dysfunctions. The questionnaire score ranges from zero (best result) to 8 (worst scenario). Patients and controls did not differ regarding the median number of ACEs (3 in both groups, patient IQR = 2.5–5 vs. control IQR = 2–5, p = 0.45). Among the patients, 63.8% (201/315) presented ACE score ≥ 3, compared with 59.9% (163/272) of the controls (p = 0.31). The proportion of patients with at least 3 ACEs did also not differ among those with different rheumatic diseases. Specifically, 64% (64/100) of those with SLE, 60% (24/40) of those with SSc, 60% (36/60) of those with SpA, and 66.9% (77/115) of those with RA reported at least 3 ACEs. There was also no difference between the distribution of ACE scores and number of individuals with ACEs ≥ 3 between patients with different rheumatic diseases and controls. Nevertheless, there was a trend for association between higher ACE score and susceptibility to RA (p = 0.06). In this setting, the occurrence of ACEs was not associated with susceptibility to rheumatic diseases in adulthood. |
| Databáze: | OpenAIRE |
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