MR imaging of thymomas: a combined radiomics nomogram to predict histologic subtypes
| Autor: | Jialiang Ren, Xiao-Yan Qu, Wu-Ping Wang, Yu Han, Wei-Qiang Yan, Jiao Ma, Gang Xiao, Guangbin Cui, Qiang Tian, Jia-Cheng Han, Peng Qin, Wen Wang, Shu-Mei Wang, Wei-Cheng Rong, Yu-Chuan Hu |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Thymoma 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Radiomics medicine Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging In patient Neuroradiology Retrospective Studies medicine.diagnostic_test Receiver operating characteristic analysis business.industry Magnetic resonance imaging General Medicine Thymus Neoplasms Nomogram Mr imaging Magnetic Resonance Imaging Nomograms 030220 oncology & carcinogenesis Radiology business |
| Zdroj: | European radiology. 31(1) |
| ISSN: | 1432-1084 |
| Popis: | Accurately predicting the WHO classification of thymomas is urgently needed to optimize individualized therapeutic strategies. We aimed to develop and validate a combined radiomics nomogram for personalized prediction of histologic subtypes in patients with thymomas. A total of 182 thymoma patients were divided into training (n = 128) and test (n = 54) cohorts. Radiomics features were extracted from T2-weighted, T2-weighted fat suppression, and diffusion-weighted images to establish a radiomics signature in the training cohort. Multivariate logistic regression analysis was used to develop a combined radiomics nomogram that incorporated clinical, conventional MR imaging variables, apparent diffusion coefficient (ADC) value, and radiomics signature. The efficacy of clinical, conventional MR imaging, or ADC model was also evaluated respectively. The performances of different models were compared by receiver operating characteristic analysis and Delong test. The discrimination, calibration, and clinical usefulness of the combined radiomics nomogram were assessed. The radiomics signature, consisting of 14 features, achieved favorable predictive efficacy in differentiating low-risk from high-risk thymomas, outperforming clinical, conventional MR imaging, and ADC models. The combined radiomics nomogram incorporating tumor shape, ADC value, and radiomics signature yielded the best performance (training cohort: area under the curve [AUC] = 0.946, test cohort: AUC = 0.878). The calibration curve and decision curve analysis indicated the clinical utility of the combined radiomics nomogram. The radiomics signature is a useful tool that can be used to predict histologic subtypes of thymomas. The combined radiomics nomogram improved the individualized subtype prediction in patients with thymomas. • Fourteen robust features were selected to develop a radiomics signature for preoperative prediction of thymoma subtype. • MRI-based radiomics signature can differentiate low-risk thymomas from high-risk thymomas with favorable predictive efficacy compared with clinical, conventional MR imaging, and ADC models. • Combined radiomics nomogram based on tumor shape, ADC value, and radiomics signature could improve the individualized subtype prediction in patients with thymomas. |
| Databáze: | OpenAIRE |
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