Serum and tissue tocopherol in sheep after intramuscular injection and(or) dietary vitamin E supplementation
| Autor: | N.S. Wilkinson, S N Williams, C A Njeru, Lee Russell McDowell, S B Linda, L.X. Rojas |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Microgram medicine.medical_treatment Administration Oral Dietary vitamin Injections Intramuscular Absorption Random Allocation Internal medicine Genetics medicine Animals Vitamin E Tissue Distribution Tocopherol Pancreas Kidney Analysis of Variance Sheep business.industry Muscles Myocardium Repeated measures design General Medicine Neck muscles medicine.anatomical_structure Endocrinology Liver Animal Science and Zoology Intramuscular injection business Neck Food Science |
| Zdroj: | Journal of animal science. 72(3) |
| ISSN: | 0021-8812 |
| Popis: | In a 28-d trial, 35 wethers weighing 35 to 60 kg were used to evaluate serum, liver, pancreas, kidney, diaphragm, heart, and neck muscle alpha-tocopherol concentrations after vitamin E administration as i.m. injections and(or) oral supplementation. Treatments (T) were as follows: 1) i.m. DL-alpha-tocopherol(DL-alpha-ol) d 1, 2) i.m. DL-alpha-tocopheryl acetate(DL-alpha-ac) d 1, 3) i.m. DL-alpha-ol d 1, 7, 14, and 21, 4) T 1 and oral supplementation, 5) T 3 and oral supplementation, 6) oral supplementation, and 7) control, no E supplementation. Supplemented wethers received 500 IU via injection and(or) 30 IU/kg of diet (acetate form). In a second 10-d trial, blood was periodically collected from 20 wethers weighing 32 to 47 kg that had been assigned to T as follows: 1) control, 2) i.m. DL-alpha-ol d 1, 3) i.m. DL-alpha-ac d 1, 4) T 2 d 1 and 7, and 5) T 3 d 1 and 7. Results from repeated measures ANOVA in both trials indicated that there were day x T effects (P < .0001) on serum alpha-tocopherol. Pretreatment serum tocopherol concentrations were .58 and .66 microgram/mL for Trials 1 and 2, respectively. In Trial 1, wethers receiving the four alcohol vitamin E forms showed a rapid increase in serum tocopherol between d 1 and 3, followed by a rapid decline to pretreatment concentrations for T 1, whereas T 3, 4, and 5 maintained higher than pretreatment concentrations after the decline.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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