Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer : a multi-institutional study
| Autor: | Elaine M. Walsh, Janina Kulka, Angelika Reiner, Cecily Quinn, Xavier Andreu, Ales Ryska, Päivi Heikkilä, Mark O’Loughlin, Grace Callagy, Paulo Figueiredo, Peter Regitnig, Elisabeth Specht Stovgaard, Sharon A. Glynn, Ewa Chemielik, Aliaa Shalaby, Giuseppe Floris, Inta Liepniece-Karele, Alicia Cordoba, Maria Pia Foschini, Anna Sapino, Gábor Cserni, Vicky Zolota, Simonetta Bianchi |
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| Přispěvatelé: | Department of Pathology, Medicum, Clinicum, O’Loughlin, Mark, Andreu, Xavier, Bianchi, Simonetta, Chemielik, Ewa, Cordoba, Alicia, Cserni, Gábor, Figueiredo, Paulo, Floris, Giuseppe, Foschini, Maria P., Heikkilä, Päivi, Kulka, Janina, Liepniece-Karele, Inta, Regitnig, Peter, Reiner, Angelika, Ryska, Ale, Sapino, Anna, Shalaby, Aliaa, Stovgaard, Elisabeth Specht, Quinn, Cecily, Walsh, Elaine M., Zolota, Vicky, Glynn, Sharon A., Callagy, Grace |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology BIOMARKER Cancer Research Triple Negative Breast Neoplasms Stromal tumour infiltrating lymphocyte 0302 clinical medicine Odds Ratio Tumor Microenvironment Triple-negative breast cancer Observer Variation sTIL Middle Aged CHEMOTHERAPY Prognosis Predictive value Neoadjuvant Therapy 3. Good health PROGNOSTIC VALUE 030220 oncology & carcinogenesis SURVIVAL Biomarker (medicine) Female TRIAL TILS Life Sciences & Biomedicine Adult medicine.medical_specialty Stromal cell CARCINOMA Concordance 3122 Cancers sTILs Neoadjuvant chemotherapy 03 medical and health sciences Young Adult Breast cancer Lymphocytes Tumor-Infiltrating Internal medicine medicine Carcinoma Biomarkers Tumor Humans Inter-observer agreement Pathological complete response Stromal tumour infiltrating lymphocytes Aged Neoplasm Staging Reproducibility Science & Technology business.industry WORKING GROUP Reproducibility of Results medicine.disease 030104 developmental biology 3111 Biomedicine Neoplasm Grading business |
| Popis: | BACKGROUND: Several studies have demonstrated a prognostic role for stromal tumour infiltrating lymphocytes (sTILs) in triple-negative breast cancer (TNBC). The reproducibility of scoring sTILs is variable with potentially excellent concordance being achievable using a software tool. We examined agreement between breast pathologists across Europe scoring sTILs on H&E-stained sections without software, an approach that is easily applied in clinical practice. The association between sTILs and response to anthracycline-taxane NACT was also examined. METHODOLOGY: Pathologists from the European Working Group for Breast Screening Pathology scored sTILs in 84 slides from 75 TNBCs using the immune-oncology biomarker working group guidance in two circulations. There were 16 participants in the first and 19 in the second circulation. RESULTS: Moderate agreement was achieved for absolute sTILs scores (intraclass correlation coefficient (ICC) = 0.683, 95% CI 0.601-0.767, p-value |
| Databáze: | OpenAIRE |
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