Cyclodextrin-Activated Porphyrin Photosensitization for Boosting Self-Cleavable Drug Release

Autor:	Mian Tang, Yanqiu Song, Yi-Lin Lu, Ying-Ming Zhang, Zhilin Yu, Xiufang Xu, Yu Liu
Rok vydání:	2022
Předmět:	Cyclodextrins Drug Liberation Drug Delivery Systems Porphyrins Photochemotherapy Drug Discovery Molecular Medicine Prodrugs
Zdroj:	Journal of Medicinal Chemistry. 65:6764-6774
ISSN:	1520-4804 0022-2623
Popis:	Supramolecular prodrugs that combine the merits of stimuli-responsiveness and targeting ability in a controllable manner have shown appealing prospects in disease diagnostics and therapeutics. Herein, we report that a new theranostic agent with the host-guest-binding-activated photosensitization has been fabricated by a binary supramolecular assembly consisting of the permethyl-β-cyclodextrin-grafted hyaluronic acid and a combretastatin A-4-appended porphyrin derivative. Illuminated by a red-light source, the production efficiency of singlet oxygen (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644dd605d461d12652dd003e3fd75db1 https://doi.org/10.1021/acs.jmedchem.2c00105 Zobrazit plný text záznamu