New Basal Insulins: a Clinical Perspective of Their Use in the Treatment of Type 2 Diabetes and Novel Treatment Options Beyond Basal Insulin
| Autor: | Patrick Frias, Juan Pablo Frias |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes Hypoglycemia Glucagon-Like Peptide-1 Receptor 03 medical and health sciences 0302 clinical medicine Glucagon-Like Peptide 1 Diabetes mellitus Internal medicine Internal Medicine medicine Humans Hypoglycemic Agents Insulin 030212 general & internal medicine Glycemic business.industry medicine.disease Endocrinology Basal (medicine) Diabetes Mellitus Type 2 Pharmacodynamics Hyperglycemia business |
| Zdroj: | Current diabetes reports. 17(10) |
| ISSN: | 1539-0829 |
| Popis: | The purpose of this review was to review advances in basal insulin formulations and new treatment options for patients with type 2 diabetes not achieving glycemic targets despite optimized basal insulin therapy. Advances in basal insulin formulations have resulted in products with increasingly favorable pharmacokinetic and pharmacodynamic properties, including flatter, peakless action profiles, less inter- and intra-patient variability, and longer duration of activity. These properties have translated to significantly reduced risk of hypoglycemia (particularly during the night) compared with previous generation basal insulins. When optimized basal insulin therapy is not sufficient to obtain or maintain glycemic goals, various options exist to improve glycemic control, including intensification of insulin therapy with the addition of prandial insulin or changing to pre-mixed insulin and, more recently, the addition of a GLP-1 receptor agonist, either as a separate injection or as a component of one of the new fixed-ratio combinations of a basal insulin and GLP-1 RA. New safer and often more convenient basal insulins and fixed ratio combinations containing basal insulin (and GLP-1 receptor agonist) are available today for patients with type 2 diabetes not achieving glycemic goals. Head-to-head studies comparing the latest generation basal insulins are underway, and future studies assessing the fixed-ratio combinations will be important to better understand their differentiating features. |
| Databáze: | OpenAIRE |
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