Leptin and Obesity: Role and Clinical Implication
| Autor: | Milan Obradovic, Emina Sudar-Milovanovic, Sanja Soskic, Magbubah Essack, Swati Arya, Alan J. Stewart, Takashi Gojobori, Esma R. Isenovic |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Leptin medicine.medical_specialty obesity Endocrinology Diabetes and Metabolism Hypothalamus Adipose tissue 030209 endocrinology & metabolism White adipose tissue Review Satiety Response Diseases of the endocrine glands. Clinical endocrinology leptin-based therapies Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Internal medicine medicine Lipolysis Animals Humans leptin receptor 2. Zero hunger Leptin receptor business.industry digestive oral and skin physiology medicine.disease RC648-665 Obesity leptin resistance 030104 developmental biology business Energy Metabolism hormones hormone substitutes and hormone antagonists Signal Transduction |
| Zdroj: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 12 (2021) |
| ISSN: | 1664-2392 |
| Popis: | The peptide hormone leptin regulates food intake, body mass, and reproductive function and plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis. Leptin is a product of the obese (ob) gene and, following synthesis and secretion from fat cells in white adipose tissue, binds to and activates its cognate receptor, the leptin receptor (LEP-R). LEP-R distribution facilitates leptin’s pleiotropic effects, playing a crucial role in regulating body mass via a negative feedback mechanism between adipose tissue and the hypothalamus. Leptin resistance is characterized by reduced satiety, over-consumption of nutrients, and increased total body mass. Often this leads to obesity, which reduces the effectiveness of using exogenous leptin as a therapeutic agent. Thus, combining leptin therapies with leptin sensitizers may help overcome such resistance and, consequently, obesity. This review examines recent data obtained from human and animal studies related to leptin, its role in obesity, and its usefulness in obesity treatment. |
| Databáze: | OpenAIRE |
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