Antibacterial Effect of a 4x Cu-TiO2 Coating Simulating Acute Periprosthetic Infection—An Animal Model
| Autor: | Sebastian Krinner, Christoph Schörner, Frank Heidenau, Stefanie Stenglein, Stefan Schulz-Drost, Raimund Forst, Werner Adler, Andreas Mauerer, Dominic Taylor |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pharmaceutical Science Periprosthetic Antibacterial effect engineering.material medicine.disease_cause Analytical Chemistry 03 medical and health sciences 0302 clinical medicine Animal model Coating In vivo Medizinische Fakultät Drug Discovery Medicine 030212 general & internal medicine antibacterial Cu-TiO2 coating acute implant-associated infection animal model total knee arthroplasty copper-ions ddc:610 Physical and Theoretical Chemistry 030222 orthopedics business.industry Organic Chemistry FEMORAL CONDYLE Infection rate Surgery Chemistry (miscellaneous) Staphylococcus aureus engineering Molecular Medicine business |
| Zdroj: | Molecules; Volume 22; Issue 7; Pages: 1042 |
| Popis: | The purpose of our study was to investigate the antibacterial effect of a spacer (Ti6Al4V) coated with 4x Cu-TiO₂ in an animal model simulating an acute periprosthetic infection by Staphylococcus aureus. Ti6Al4 bolts contaminated with Staphylococcus aureus were implanted into the femoral condyle of rabbits (n = 36) divided into 3 groups. After one week in group 1 (control) the bolts were removed without any replacement. In group2 Ti6Al4V bolts with a 4x Cu-TiO₂ coating and in group 3 beads of a gentamicin-PMMA chain were imbedded into the borehole. Microbiological investigation was performed at the primary surgery, at the revision surgery and after scarification of the rabbits 3 weeks after the first surgery. Blood tests were conducted weekly. The initial overall infection rate was 88.9%. In group 2 and 3 a significant decrease of the infection rate was shown in contrast to the control group. The C-reactive protein (CRP) levels declined one week after the first surgery except in the control group where the CRP level even increased. This is the first in vivo study that demonstrated the antibacterial effects of a fourfold Cu-TiO₂ coating. For the future, the coating investigated could be a promising option in the treatment of implant-associated infections. |
| Databáze: | OpenAIRE |
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