Plasma metabolites Xanthine, 4-Pyridoxate, and d-glutamic acid as novel potential biomarkers for pulmonary tuberculosis
| Autor: | Huai Huang, Wen-Jing Yi, Ji-Cheng Li, Jing Chen, Zhi-Bin Li, Li-Liang Wei, Hui-Hui Tu, Li-Ying Shi, Zhi-Wen Pan, Yu-Ting Hu, Yu-Shuai Han, Ting-Ting Jiang |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Lung Neoplasms Clinical Biochemistry Virulence Pharmacology Xanthine Biochemistry Mycobacterium tuberculosis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Metabolomics Glutamates Tandem Mass Spectrometry medicine Humans Lung cancer Tuberculosis Pulmonary Chromatography High Pressure Liquid biology business.industry Biochemistry (medical) Computational Biology General Medicine Glutamic acid Middle Aged biology.organism_classification medicine.disease Community-Acquired Infections Pneumonia 030104 developmental biology chemistry Case-Control Studies 030220 oncology & carcinogenesis Female Energy source business Biomarkers Pyridoxic Acid |
| Zdroj: | Clinica Chimica Acta. 498:135-142 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2019.08.017 |
| Popis: | Background The lack of rapid and efficient diagnostic methods has been one of the most frustrating challenges in controlling the pulmonary tuberculosis (TB) epidemic. This study was aimed to identify novel non-invasive biomarkers for pulmonary TB. Methods The subjects in this study were divided into four groups: the pulmonary TB group, the community-acquired pneumonia (CAP) group, the lung cancer (LC) group, and the normal control (NC) group. Plasma small molecule metabolites were investigated in each group by using ultra-high performance liquid chromatography coupled with Q Exactive mass spectrometry. Multivariate statistical methods and bioinformatics were used to analyze the data. Results We identified three differential plasma metabolites such as, Xanthine, 4-Pyridoxate and d -glutamic acid in the pulmonary TB group, compared to the other groups (CAP, LC and NC). The pathway enrichment analysis indicated that the energy source in pulmonary TB was multi-center, which might be involved in maintaining the reproductive ability and virulence of Mycobacterium tuberculosis. Conclusion The results suggested that Xanthine, 4-Pyridoxate, and d -glutamic acid may serve as potential biomarkers for pulmonary TB. The present study provides experimental basis for developing potential biomarkers of pulmonary TB. |
| Databáze: | OpenAIRE |
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