Immediate breast reconstruction surgery with expander/direct implant and use of acellular dermal matrix: Does hormone therapy increases the risk of infection?
| Autor: | A. El Khatib, G. Dimitropoulos, D. Giaccone, Joseph Bou-Merhi, M. Retchkiman, Alain R. Gagnon, Michel Alain Danino, Christina Bernier, O. Doucet |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Mammaplasty Breast Neoplasms 030230 surgery 03 medical and health sciences 0302 clinical medicine Breast cancer medicine Humans Acellular Dermis Prospective Studies skin and connective tissue diseases Mastectomy Retrospective Studies business.industry Capsular contracture medicine.disease Hormones Surgery Seroma Hormonal therapy Female Hormone therapy business Breast reconstruction Tamoxifen medicine.drug |
| Zdroj: | Annales de chirurgie plastique et esthetique. 65(4) |
| ISSN: | 1768-319X |
| Popis: | Summary Background The use of hormone therapy (tamoxifen and aromatase inhibitors) has been shown to increase venous thromboembolism. However, while estrogens play a crucial role in wound healing, no study has assessed the impact of tamoxifen or aromatase inhibitors on other postoperative breast reconstruction complications, including infections, necrosis, capsular contracture and seroma. As breast cancer patients undergoing Implants-ADMs breast reconstruction are often receiving hormone therapy, it is unclear whether this increased infection risk is associated with increased infections cases. Methods A prospective study was performed on patients undergoing breast reconstruction at an academic institution from 2013 to 2016. Patients were divided by use of hormone therapy at the time of surgery. Complication rates, including infections, necrosis, seroma and hematomas, were compared and analyzed using univariate and logistic regression models. Results Among a total of 112 patients (183breasts), 58 patients (91 breasts) were receiving hormone therapy and 54 patients (92 breasts) were not. The hormone therapy group had a higher incidence of postoperative mastectomy skin infection (20.7% versus 7.4%; P = 0.0447), we didn’t find any significant differences in necrosis. Conclusions Hormone therapy was associated with a higher incidence of Infections after breast reconstruction with ADMs and implants. The authors propose an individualized approach to the preoperative cessation of tamoxifen or aromatase inhibitors. Immediate breast reconstruction surgery with expander/direct implant and use of acellular dermal matrix: does hormone therapy increases the risk of infection? |
| Databáze: | OpenAIRE |
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