Mesulergine antagonism towards the fluoxetine anti-immobility effect in the forced swimming test in mice
| Autor: | C. Ciprandi, R. Cesana, Franco Borsini, A Ceci |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Ratón Pharmaceutical Science Pharmacology chemistry.chemical_compound Immobilization Mice Internal medicine Dopamine receptor D2 Fluoxetine medicine Animals Drug Interactions Neurotransmitter Uptake Inhibitors Ergolines Mesulergine Swimming Behavior Animal Dose-Response Relationship Drug Depression Antagonist Disease Models Animal Endocrinology Mechanism of action chemistry Receptors Serotonin medicine.symptom Antagonism Behavioural despair test medicine.drug |
| Zdroj: | The Journal of pharmacy and pharmacology. 45(5) |
| ISSN: | 0022-3573 |
| Popis: | The anti-immobility effect of fluoxetine (40 mg kg−1) in the forced swimming test in mice was antagonized by the 5-HT1c/2 antagonist mesulergine (7·5 mg kg−1) and the dopamine D2 antagonist (±)-sulpiride (12.5 mg kg−1) but not by the 5-HT2/1C antagonist ritanserine (2 mg kg−1), the 5-HT1A/1B antagonist (–)-propranolol (20 mg kg−1) or the 5-HT3 antagonist DAU 6215 (0·1 mg kg−1). All compounds were administered intraperitoneally (i.p.) 6 min before fluoxetine, given i.p. 30 min before testing. The anti-immobility effect of fluoxetine was also prevented by pretreat-ment with p-chlorophenylalanine (300 mg kg−1 twice daily for 3 days) which produced an 80% reduction of 5-HT in brain. The results suggest that fluoxetine reduces immobility time in mice forced to swim, by acting indirectly through a mesulergine-sensitive site, probably the 5-HT1C receptor. |
| Databáze: | OpenAIRE |
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