Patients with chronic mild or moderate traumatic brain injury have abnormal brain enlargement
| Autor: | Leah Cooper, Alfred L. Ochs, John D Seabaugh, Jan M. Seabaugh, Laura Peyton Ellis, David E. Ross, Christopher Stephen Hall, Christopher Reese, Claudia Alvarez, Christopher Powell |
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| Rok vydání: | 2019 |
| Předmět: |
030506 rehabilitation
medicine.medical_specialty Traumatic brain injury Neuroscience (miscellaneous) Muscle hypertrophy 03 medical and health sciences 0302 clinical medicine Atrophy Neuroimaging Internal medicine Brain Injuries Traumatic Parenchyma Developmental and Educational Psychology medicine Humans Mri scan medicine.diagnostic_test business.industry Brain Magnetic resonance imaging Hypertrophy medicine.disease Magnetic Resonance Imaging Brain Injuries Brain size Cardiology Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Brain Injury. 34:11-19 |
| ISSN: | 1362-301X 0269-9052 |
| DOI: | 10.1080/02699052.2019.1669074 |
| Popis: | Introduction: Much less is known about brain volume abnormalities in patients with chronic mild or moderate traumatic brain injury (TBI) compared with patients with more severe injury. Commercially available software methods including NeuroQuant® are being used increasingly to assess MRI brain volume in patients with TBI.Methods: 50 patients with mild or moderate TBI were compared to the NeuroQuant® normal control database (n = thousands) with respect to MRI brain volume.Results: The patients had many areas of abnormal enlargement and fewer areas of atrophy, including abnormally small cerebral white matter (CWM) limited to the first 10 months after injury. Examination of correlations within the patient group between CWM volume and volumes of the abnormally enlarged regions showed multiple significant negative correlations, indicating that CWM atrophy correlated with enlargement of the other regions.Discussion: The finding of many regions of abnormal brain enlargement was relatively new, although a couple of previous studies of patients with mild TBI found similar but more limited findings. The cause of the abnormal enlargement was unknown, but possibilities included: (1) hyperactivity and hypertrophy; or (2) chronic neuro-inflammation and edema.Abbreviations: ADNI: Alzheimer's Disease Neuroimaging Initiative; CWM: cerebral white matter; GM: cerebral cortical gray matter; ICC: intraclass correlations coefficient; IFT: infratentorial; MRI: magnetic resonance imaging; mTBI: mild TBI; NQ: NeuroQuant®; SCN: subcortical nuclei; t0: time of injury; t1: time of first NeuroQuanted MRI scan after injury; t2: time of second NeuroQuanted MRI scan after injury; TBI: traumatic brain injury; VBR: ventricle-to-brain ratio; WBP: whole-brain parenchyma. |
| Databáze: | OpenAIRE |
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