Pleiotropic modulation of thymic functions by growth hormone: from physiology to therapy

Autor: Mireille Dardenne, Wilson Savino
Přispěvatelé: Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Cytokines, hématopoïèse et réponse immune (CHRI), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), This work was developed in the context of the CNRS-Fiocruz Associated Laboratory of Immunology and Immunopathology. It was partially funded with grants by CNRS/Fiocruz French/Brazilian conjoint program, Fiocruz, CNPq, Capes and Faperj (Brazil), and CNRS (France).
Rok vydání: 2010
Předmět:
Chemokine
medicine.medical_specialty
MESH: Growth Hormone/physiology
Neuroimmunomodulation
MESH: Mice
Transgenic
T-Lymphocytes
[SDV]Life Sciences [q-bio]
Transgene
MESH: Epithelial Cells/physiology
Mice
Transgenic
Context (language use)
Thymus Gland
Biology
Receptor
IGF Type 1
Mice
Immune system
Internal medicine
MESH: Insulin-Like Growth Factor I/physiology
Drug Discovery
medicine
Animals
Humans
MESH: Animals
Secretion
Insulin-Like Growth Factor I
Receptor
MESH: Mice
Immunodeficiency
Pharmacology
MESH: Humans
Human Growth Hormone
Epithelial Cells
MESH: Genes
T-Cell Receptor/physiology
medicine.disease
MESH: Human Growth Hormone/physiology
Genes
T-Cell Receptor
MESH: Thymus Gland/physiology
Thymocyte
MESH: Receptor
IGF Type 1/physiology
Endocrinology
MESH: Neuroimmunomodulation
Growth Hormone
MESH: T-Lymphocytes/physiology
biology.protein
Zdroj: Current Opinion in Pharmacology
Current Opinion in Pharmacology, Elsevier, 2010, 10, pp.434-442. ⟨10.1016/j.coph.2010.04.002⟩
ISSN: 1471-4892
DOI: 10.1016/j.coph.2010.04.002
Popis: International audience; In the context of the cross-talk between the neuroendocrine and immune systems, it is well known that growth hormone (GH) exerts physiological effects in central as well as peripheral compartments of the immune system. GH modulates a variety of thymic functions, including proliferation of thymocytes and thymic epithelial cells (TEC). Accordingly, GH-transgenic mice, as well as animals and humans treated with exogenous GH, exhibit an enhanced cellularity in the organ. GH also stimulates the secretion of cytokines and chemokines by the thymic microenvironment, as well as the production of extracellular matrix proteins. These effects lead to an increase in thymocyte migratory responses and intrathymic traffic of developing T cells, including the export of thymocytes from the organ, as ascertained by experimental studies with intrathymic injection of GH in normal mice and with GH-transgenic animals. Most likely, GH effects in the thymus are mediated by an IGF-1/IGF-1 receptor circuitry, which physiologically operates in nonstimulated conditions in both thymocytes and TECs. Since GH enhances thymus replenishment and increases intrathymic T-cell traffic, ultimately modulating thymocyte exit, it should be placed as a potential adjuvant therapeutic agent in the treatment of immunodeficiencies associated with thymic atrophy, and examples recently appeared in the literature are promising and strongly indicate that GH can be beneficial for individuals suffering severe immunodeficiency.
Databáze: OpenAIRE
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