The transcriptional and signalling networks of pluripotency
| Autor: | Huck-Hui Ng, M. Azim Surani |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pluripotent Stem Cells
RNA Untranslated Transcription Genetic food and beverages Cell Biology Biology Embryonic stem cell Cell biology Histones Mice MicroRNAs Signalling Transcription (biology) Animals Humans Signal transduction Transcription factor Signalling pathways Signal Transduction Transcription Factors |
| Zdroj: | Nature Cell Biology. 13:490-496 |
| ISSN: | 1476-4679 1465-7392 |
| Popis: | Pluripotency and self-renewal are the hallmarks of embryonic stem cells. This state is maintained by a network of transcription factors and is influenced by specific signalling pathways. Current evidence indicates that multiple pluripotent states can exist in vitro. Here we review the recent advances in studying the transcriptional regulatory networks that define pluripotency, and elaborate on how manipulation of signalling pathways can modulate pluripotent states to varying degrees. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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