Modular PET Agent Construction Strategy through Strain-Promoted Double-Click Reagent with Efficient Photoclick Step

Autor:	Manshu Li, Xinrui Ma, Christopher J. Molnar, Shuli Wang, Zhanhong Wu, Vladimir V. Popik, Zibo Li
Rok vydání:	2022
Předmět:	Pharmacology Azides Positron-Emission Tomography Alkynes Organic Chemistry Biomedical Engineering Pharmaceutical Science Bioengineering Click Chemistry Radiopharmaceuticals Biotechnology
Zdroj:	Bioconjugate chemistry. 33(11)
ISSN:	1520-4812
Popis:	An efficient modular strategy for rapid assembly of positron emission tomography (PET) agents has been developed. The use of a sequential, rapid, and selective double-click reaction allows for a combinatorial approach to the cross-linking of positron emitter-bearing prosthetic groups with various ligands. The strain-promoted azide alkyne cyclization (SPAAC) coupling of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6444b970d48faa87928541ff69f14584 https://pubmed.ncbi.nlm.nih.gov/36342263 Zobrazit plný text záznamu