Association of environmental cadmium exposure and bone remodeling in women over 50 years of age

Autor: Rui Huang, Xuxia Liang, Yingjian Lv, Jia Song, Qinzhi Wei, Shi-xuan Wu, Li-Li Xiong, Ping Wang, Pan Zhu, Xingfen Yang, Jian-Bin Tan, Jing Wang
Rok vydání: 2020
Předmět:
Health
Toxicology and Mutagenesis
Osteoporosis
0211 other engineering and technologies
02 engineering and technology
010501 environmental sciences
01 natural sciences
Environmental pollution
Bone remodeling
Body Mass Index
chemistry.chemical_compound
Bone Density
GE1-350
Bone mineral
General Medicine
Cadmium exposure
Middle Aged
Pollution
TD172-193.5
Alkaline phosphatase
Serum β-CTX
Environmental Pollutants
Female
Bone Remodeling
Cadmium
Adult
medicine.medical_specialty
Renal function
Bone and Bones
Collagen Type I
Osteoprotegerin
Internal medicine
medicine
Humans
0105 earth and related environmental sciences
Aged
021110 strategic
defence & security studies
Creatinine
business.industry
RANK Ligand
Public Health
Environmental and Occupational Health
Environmental Exposure
medicine.disease
Alkaline Phosphatase
Environmental sciences
Endocrinology
chemistry
business
Peptides
Body mass index
Biomarkers
Zdroj: Ecotoxicology and Environmental Safety, Vol 211, Iss, Pp 111897-(2021)
ISSN: 1090-2414
Popis: Chronic cadmium (Cd) toxicity is a significant health concern, and the mechanism of long-term low-dose Cd exposure on bone has not been fully elucidated yet. This study aimed to assess the association between long-term environmental Cd exposure and bone remodeling in women who aged over 50. A total of 278 non-smoking subjects from Cd-polluted group (n = 191) and non-Cd polluted group (n = 87) were investigated. Bone mineral density (BMD), the levels of three bone turnover markers (BTMs), including total procollagen type 1 amino-terminal propeptide (P1NP), collagen type 1 cross-linked C-telopeptide (β-CTX), bone-specific alkaline phosphatase (BALP), together with serum soluble receptor activator of nuclear factor-κB ligand (sRANKL) and osteoprotegerin (OPG) were determined. Early markers of renal dysfunction were measured as well. Urinary Cd concentrations ranged from 0.41 to 87.31 μg/g creatinine, with a median of 4.91 μg/g creatinine. Age, BMD, T-score, and prevalence of osteoporosis showed no statistical differences among the quartiles of urinary Cd concentrations, while serum levels of P1NP, β-CTX, and OPG were higher in the upper quartiles. Multivariate linear regression models indicated significantly positive associations of urinary Cd concentration with serum levels of P1NP, β-CTX, BALP, sRANKL, and OPG. A ridge regression analysis with T-score and the three BTMs, sRANKL, and OPG, adjusted for age and body mass index (BMI), indicated that except for age and Cd exposure, β-CTX was a predictor of T-score. These findings demonstrated that Cd may directly accelerate bone remodeling. Serum β-CTX might be an appropriate biochemical marker for evaluating and monitoring Cd-related bone loss. Capsule: Cadmium (Cd) may directly accelerate bone remodeling and serum β-CTX is a valuable biochemical marker for evaluating Cd-related bone loss.
Databáze: OpenAIRE
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