Contribution of sodium channel and sodium/hydrogen exchanger to sodium accumulation in the ischemic myocardium
| Autor: | Kouichi Tanonaka, Satoshi Takeo, Hiroshi Kajiwara, Ayako Takasaki |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Sodium-Hydrogen Exchangers Sodium Myocardial Ischemia Ischemia chemistry.chemical_element Tetrodotoxin In Vitro Techniques Sodium Channels Ventricular Function Left Amiloride chemistry.chemical_compound Sodium channel blocker Internal medicine medicine Animals cardiovascular diseases Rats Wistar Ions Pharmacology Ion exchange Myocardium Sodium channel medicine.disease Myocardial Contraction Rats Sodium–hydrogen antiporter chemistry Biochemistry Cardiology Sodium Channel Blockers medicine.drug |
| Zdroj: | General Pharmacology: The Vascular System. 34:167-174 |
| ISSN: | 0306-3623 |
| DOI: | 10.1016/s0306-3623(00)00057-4 |
| Popis: | Contribution of sodium channels and sodium/hydrogen exchangers (NHEs) to sodium accumulation during ischemia in the ischemic/reperfused heart was examined. Ischemia increased the myocardial sodium. Reperfusion elicited a further increase in the myocardial sodium, which was associated with little recovery of the left ventricular developed pressure (LVDP) of the perfused heart. Treatment with tetrodotoxin or dimethylamirolide (DMA) dose-dependently attenuated the ischemia- and reperfusion-induced increase in myocardial sodium and enhanced the post-ischemic recovery of the LVDP. There was an inverse relationship between the increase in myocardial sodium during ischemia and the post-ischemic recovery of the LVDP.The myocardial sodium accumulation during ischemia is mainly attributed to sodium influx through sodium channels and NHEs. |
| Databáze: | OpenAIRE |
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