Novel emerging therapies in atherosclerosis targeting lipid metabolism
| Autor: | Carl J. Lavie, Salim S. Virani, Wilbert S. Aronow, Manasvi Gupta, Raktim K. Ghosh, Kausik K. Ray, Colin Blumenthal, Vardhmaan Jain, Subhankar Chatterjee, Dhrubajyoti Bandyopadhyay |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
IMPROVE-IT CLEAR harmony evinacumab Mipomersen RATIONALE Pharmacology Inclisiran chemistry.chemical_compound DOUBLE-BLIND 0302 clinical medicine Hyperlipidemia Pharmacology (medical) Pharmacology & Pharmacy Hypolipidemic Agents EVAPORATE CHOLESTEROL INHIBITOR General Medicine ORION-10 Tolerability PCSK9 inhibitors Cardiovascular Diseases 030220 oncology & carcinogenesis Acyltransferase SAFETY lipids (amino acids peptides and proteins) ODYSSEY 1115 Pharmacology and Pharmaceutical Sciences Life Sciences & Biomedicine MIPOMERSEN TRIGLYCERIDES bempedoic acid Evinacumab Hyperlipidemias FOURIER 03 medical and health sciences medicine Animals Humans cardiovascular diseases REDUCE-IT ACYLTRANSFERASE lomitapide Pemfibrate Science & Technology Cholesterol business.industry nutritional and metabolic diseases Lipid metabolism Cholesterol LDL medicine.disease Atherosclerosis Lipid Metabolism Lomitapide 030104 developmental biology Pemafibrate chemistry APOLIPOPROTEIN(A) TOLERABILITY Hydroxymethylglutaryl-CoA Reductase Inhibitors business |
| Zdroj: | Expert opinion on investigational drugs. 29(6) |
| ISSN: | 1744-7658 |
| Popis: | INTRODUCTION: Recent years have brought significant developments in lipid and atherosclerosis research. Although statins are a cornerstone in hyperlipidemia management, new non-statin therapies have had an impact. The reduction of low-density lipoprotein cholesterol (LDL-C) further translates into the lowering of cardiovascular mortality. Additionally, lipid research has progressed beyond LDL-C reduction and this has brought triglyceride (TG) and apoprotein-B containing lipids into focus.Areas covered:Inclisiran and pemafibrate, with expected approval soon, come under the spotlight. We discuss other therapeutics such as lomitapide, mipomersen, volanesorsen and evinacumab and newly approved non statin-based therapies such as ezetimibe, icosapent ethyl (IPE) and bempedoic acid.Expert Opinion:New options now exist for the prevention of atherosclerosis in patients that are not optimized on statin therapy. Multiple guidelines endorse ezetimibe, PCSK9 inhibitors, bempedoic and IPE as add-on therapy. Recently approved bempedoic acid/ezetimibe combination might gain popularity among clinicians. Inclisiran and pemafibrate show promise in the reduction of LDL-C and TG, respectively and results are pending in cardiovascular outcome trials. Combination strategies could improve outcomes, but the challenge will be balancing cost and selecting the correct patient population for each treatment modality to maximize benefit with the fewest medications. |
| Databáze: | OpenAIRE |
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