Prognostic and Therapeutic Implications of Immune Classification by CD8+ Tumor-Infiltrating Lymphocytes and PD-L1 Expression in Sinonasal Squamous Cell Carcinoma
| Autor: | José Luis Llorente, Virginia N. Cabal, Cristina Riobello, Fernando López, Rocío García-Marín, Sara Reda, Laura Suárez-Fernández, Mario Hermsen, Blanca Vivanco, César Álvarez-Marcos |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
squamous cell carcinoma
PD-L1 QH301-705.5 medicine.medical_treatment CD8+ TILs chemical and pharmacologic phenomena Catalysis Inorganic Chemistry Immune system otorhinolaryngologic diseases Medicine Physical and Theoretical Chemistry Biology (General) Molecular Biology Survival rate QD1-999 Spectroscopy Tumor microenvironment biology business.industry Tumor-infiltrating lymphocytes Organic Chemistry General Medicine Immunotherapy Computer Science Applications Chemistry sinonasal cancer Cancer research biology.protein Immunohistochemistry immunotherapy business CD8 |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 6926, p 6926 (2021) International Journal of Molecular Sciences Volume 22 Issue 13 |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Sinonasal squamous cell carcinoma (SNSCC) is an aggressive tumor predominantly arising in the maxillary sinus and nasal cavities. Advances in imaging, surgical and radiotherapeutic techniques have reduced complications and morbidity however, the prognosis generally remains poor, with an overall 5-year survival rate of 30–50%. As immunotherapy may be a new therapeutic option, we analyzed CD8+ tumor-infiltrating lymphocytes (TILs) and the tumor microenvironment immune type (TMIT, combining CD8+ TILs and PD-L1) in a series of 57 SNSCCs. Using immunohistochemistry, tissue samples of 57 SNSCCs were analyzed for expression of CD8 on TILs and of PD-L1 on tumor cells. The results were correlated to the clinical and survival data. In total, 88% (50/57) of the tumors had intratumoral CD8+ TILs 19% (11/57)—CD8high (> 10%) and 39/57 (68%)—CD8low (1–10%). PD-L1 positivity (> 5%) was observed in 46% (26/57) of the SNSCCs and significantly co-occurred with CD8+ TILs (p = 0.000). Using univariate analysis, high intratumoral CD8+ TILs and TMIT I (CD8high/PD-L1pos) correlated with a worse survival rate. These results indicate that SNSCCs are immunogenic tumors, similar to head and neck squamous cell carcinomas. Nineteen percent of the cases were both CD8high and PD-L1pos and this subgroup may benefit from therapy with immune checkpoint inhibitors. |
| Databáze: | OpenAIRE |
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