Biology and pathology of nonmyelinating Schwann cells
| Autor: | John W. Griffin, Wesley J. Thompson |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Unmyelinated nerve fiber Neuromuscular Junction Motor nerve Biology Lower energy Cellular and Molecular Neuroscience Myelin Sympathetic Fibers Postganglionic Peripheral Nervous System medicine Animals Humans Postganglionic Sympathetic Fiber Nerve Fibers Unmyelinated Neuronal Plasticity Nerve Regeneration medicine.anatomical_structure nervous system Neurology Sympathetic Fibers Nociceptor Schwann Cells Wallerian Degeneration Neuroscience |
| Zdroj: | Glia. 56:1518-1531 |
| ISSN: | 1098-1136 0894-1491 |
| DOI: | 10.1002/glia.20778 |
| Popis: | The CNS contains relatively few unmyelinated nerve fibers, and thus benefits from the advantages that are conferred by myelination, including faster conduction velocities, lower energy consumption for impulse transmission, and greater stability of point-to-point connectivity. In the PNS many fibers or regions of fibers the Schwann do not form myelin. Examples include C fibers nociceptors, postganglionic sympathetic fibers, and the Schwann cells associated with motor nerve terminals at neuromuscular junctions. These examples retain a degree of plasticity and a capacity to sprout collaterally that is unusual in myelinated fibers. Nonmyelin-forming Schwann cells, including those associated with uninjured fibers, have the capacity to act as the "first responders" to injury or disease in their neighborhoods. |
| Databáze: | OpenAIRE |
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