Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity
| Autor: | Bruce W. Patterson, Faidon Magkos, Gemma Fraterrigo, Samuel Klein, Lisa de las Fuentes, Jun Yoshino, Shannon C. Kelly, Adewole L. Okunade, Courtney Tiemann Luecking, Songbing He, Kyleigh Kirbach |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Physiology medicine.medical_treatment Adipose tissue 030209 endocrinology & metabolism Inflammation Biology medicine.disease_cause Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Weight loss Insulin-Secreting Cells Internal medicine Weight Loss medicine Humans Insulin Obesity Molecular Biology Cholesterol Muscles Cell Biology Middle Aged medicine.disease 030104 developmental biology Endocrinology Adipose Tissue Liver chemistry Female Insulin Resistance medicine.symptom Oxidative stress |
| Zdroj: | Cell Metabolism. 23:591-601 |
| ISSN: | 1550-4131 |
| DOI: | 10.1016/j.cmet.2016.02.005 |
| Popis: | Although 5%-10% weight loss is routinely recommended for people with obesity, the precise effects of 5% and further weight loss on metabolic health are unclear. We conducted a randomized controlled trial that evaluated the effects of 5.1% ± 0.9% (n = 19), 10.8% ± 1.3% (n = 9), and 16.4% ± 2.1% (n = 9) weight loss and weight maintenance (n = 14) on metabolic outcomes. 5% weight loss improved adipose tissue, liver and muscle insulin sensitivity, and β cell function, without a concomitant change in systemic or subcutaneous adipose tissue markers of inflammation. Additional weight loss further improved β cell function and insulin sensitivity in muscle and caused stepwise changes in adipose tissue mass, intrahepatic triglyceride content, and adipose tissue expression of genes involved in cholesterol flux, lipid synthesis, extracellular matrix remodeling, and oxidative stress. These results demonstrate that moderate 5% weight loss improves metabolic function in multiple organs simultaneously, and progressive weight loss causes dose-dependent alterations in key adipose tissue biological pathways. |
| Databáze: | OpenAIRE |
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