Liver microsomal phosphatidyl choline biosynthesis in choline deficiency
| Autor: | W. E. Cornatzer, David N. Skurdal |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
medicine.medical_specialty
Methyltransferase General Biochemistry Genetics and Molecular Biology Choline Phosphotransferase chemistry.chemical_compound Biosynthesis Internal medicine medicine Animals Liver microsomes Choline Deficiency Phosphatidylethanolamines Phosphotransferases Methyltransferases Dietary Fats Rats Endocrinology chemistry Biochemistry Microsome Microsomes Liver Phosphatidylcholines Phosphatidyl choline Female |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 145(3) |
| ISSN: | 0037-9727 |
| Popis: | SummaryIn choline deficiency, there is a decrease in activity of the phosphatidyl ethanolamine methyltransferase of liver microsomes. There is an impairment in the conversion of phosphatidyl ethanolamine to phosphatidyl choline via the Bremer-Green-berg pathway. The phosphatidyl choline synthesized via the Kennedy pathway shows that the choline phosphotransferase activity is unaltered in animals fed a diet made choline deficient by feeding 5% casein-5% fat and 1% guanidoacetic acid when compared to controls fed a 25% casein-5% fat diet. However in animals fed Purina laboratory chow which contains 2.4 mg choline/g diet, the choline phosphotransferase activity is 3.8 times greater than the values from rats fed the 25% casein-5% fat diet with no dietary choline. |
| Databáze: | OpenAIRE |
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