Rapid Spread and Diversification of Respiratory Syncytial Virus Genotype ON1, Kenya

Autor: Caroline W. Gitahi, Patricia A. Cane, James R. Otieno, D. James Nokes, Charles N. Agoti
Rok vydání: 2014
Předmět:
Male
Most recent common ancestor
Genes
Viral
Epidemiology
viruses
respiratory syncytial virus
lcsh:Medicine
medicine.disease_cause
Viral Envelope Proteins
Gene duplication
Genotype
Phylogeny
Genetics
Molecular Epidemiology
0303 health sciences
Mutation
Phylogenetic tree
RSV
ON1
genotype ON1
3. Good health
Infectious Diseases
Child
Preschool
surveillance
Female
Seasons
Microbiology (medical)
Molecular Sequence Data
Respiratory Syncytial Virus Infections
Biology
epidemics
lcsh:Infectious and parasitic diseases
attachment protein
03 medical and health sciences
Phylogenetics
respiratory viruses
medicine
Humans
pneumonia
G protein gene
lcsh:RC109-216
Amino Acid Sequence
Gene
030304 developmental biology
Molecular epidemiology
030306 microbiology
Research
phylogenetic analysis
lcsh:R
Infant
Newborn
G glycoprotein
Kenya
Virology
Respiratory Syncytial Virus
Human
Sequence Alignment
Zdroj: Emerging Infectious Diseases, Vol 20, Iss 6, Pp 950-959 (2014)
Emerging Infectious Diseases
ISSN: 1080-6059
1080-6040
DOI: 10.3201/eid2006.131438
Popis: Surveillance of this new genotype helps clarify the mechanisms of rapid emergence of respiratory viruses.
Respiratory syncytial virus genotype ON1, which is characterized by a 72-nt duplication in the attachment protein gene, has been detected in >10 countries since first identified in Ontario, Canada, in 2010. We describe 2 waves of genotype ON1 infections among children admitted to a rural hospital in Kenya during 2012. Phylogenetic analysis of attachment protein gene sequences showed multiple introductions of genotype ON1; variants distinct from the original Canadian viruses predominated in both infection waves. The genotype ON1 dominated over the other group A genotypes during the second wave, and some first wave ON1 variants reappeared in the second wave. An analysis of global genotype ON1 sequences determined that this genotype has become considerably diversified and has acquired signature coding mutations within immunogenic regions, and its most recent common ancestor dates to ≈2008–2009. Surveillance of genotype ON1 contributes to an understanding of the mechanisms of rapid emergence of respiratory viruses.
Databáze: OpenAIRE
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