E-Selectin and markers of HIV disease severity, inflammation and coagulation in HIV-infected treatment-naïve individuals
| Autor: | Annalise E Zemlin, Madelein Hoffman, Dineo V. Phatlhane, Hayley Ipp, Rajiv T Erasmus |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Population inflammation and coagulation in HIV-infected treatment-naïve individuals Inflammation HIV Infections Disease CD38 Fibrinogen Severity of Illness Index Fibrin Fibrinogen Degradation Products 03 medical and health sciences Leukocyte Count 0302 clinical medicine E-selectin medicine Humans 030212 general & internal medicine education Blood Coagulation education.field_of_study biology business.industry Albumin General Medicine Articles Atherosclerosis ADP-ribosyl Cyclase 1 E-selectin inflammation and coagulation in HIV-infected treatment-naïve individuals CD4 Lymphocyte Count 030104 developmental biology Cross-Sectional Studies Coagulation Immunology biology.protein Female medicine.symptom Inflammation Mediators business Biomarkers medicine.drug |
| Zdroj: | African Health Sciences; Vol 18, No 4 (2018); 1066-1075 African Health Sciences |
| ISSN: | 1680-6905 |
| Popis: | Background: E-selectin has been shown to play a role in atherosclerosis and to be increased in HIV-infected individuals due to chronic immune activation. There is a paucity of studies on E-selectin in HIV-infected treatment-naive individuals. Objectives: This study aimed to determine whether E-selectin levels were increased in HIV-infected treatment-naive individuals and whether these correlated with markers of disease severity, inflammation and coagulation to determine if this population is at risk for cardiovascular disease (CVD). Methods: E-selectin levels were determined in 114 HIV-infected treatment-naive and 66 HIV-negative individuals, compared between groups and correlated with markers of disease severity, inflammation and coagulation. Results: There were statistically significant differences (p |
| Databáze: | OpenAIRE |
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