Beneficial effect of medicinal plants on the contractility of post-hypoxic isolated guinea pig atria – Potential implications for the treatment of ischemic–reperfusion injury

Autor:	Robbert Bipat, Jerry R. Toelsie, Jennifer Pawirodihardjo, Angelique Wangsawirana, R.C. Soekhoe, Krishan Oedairadjsingh, Karin Stender, I. Magali, Dennis R. A. Mans
Rok vydání:	2016
Předmět:	Cardiotonic Agents Time Factors Guinea Pigs Pharmaceutical Science Myocardial Reperfusion Injury In Vitro Techniques 030204 cardiovascular system & hematology 01 natural sciences Contractility 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Discovery Botany Animals Heart Atria Hypoxia Annona muricata Pharmacology Higenamine Plants Medicinal Combretaceae Dose-Response Relationship Drug biology Traditional medicine Plant Extracts Terminalia General Medicine Cecropia peltata Atrial Function biology.organism_classification Moraceae Myocardial Contraction 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry Molecular Medicine Bixaceae Phytotherapy
Zdroj:	Pharmaceutical Biology. 54:1483-1489
ISSN:	1744-5116 1388-0209
DOI:	10.3109/13880209.2015.1107103
Popis:	Context Ischemic-reperfusion injury is accompanied by a decreased contractility of the myocardium. Positive-inotropic agents have proven useful for treating this condition but may exert serious side-effects. Objective In this study, aqueous preparations from Abelmoschus esculentus L. Moench (Malvaceae), Annona muricata L. (Annonaceae), Bixa orellana L. (Bixaceae), Cecropia peltata L. (Moraceae), Erythrina fusca Lour. (Fabaceae), Psidium guajava L. (Myrtaceae) and Terminalia catappa L. (Combretaceae) were evaluated for their ability to improve the decreased contractility of isolated guinea pig atria after hypoxic stress. Materials and methods Guinea pig atria isolated in Ringer-Locke buffer gassed with 100% O2 at 30 °C were exposed for 5 min to hypoxia, then allowed to recover in oxygenated buffer alone or containing a single plant extract (0.001-1 mg/mL). The contractility (g/s) and beating frequency (beats/min), as well as troponin C contents of the bathing solution (ng/mL), were determined and expressed as means ± SDs. Results The extracts of A. muricata, B. orellana, C. peltata and T. catappa caused an increase in the contractility compared to untreated atria of 340 ± 102%, 151 ± 13%, 141 ± 14% and 238 ± 44%, respectively. However, the latter two preparations increased the troponin C contents of the bathing solution to 36 ± 11 and 69 ± 33, compared to the value of 11 ± 3 ng/mL found with untreated atria. Conclusions Preparations from A. muricata and B. orellana may possess positive-inotropic properties which may improve the contractility of the post-hypoxic myocardium. Studies to assess their usefulness in ischemic-reperfusion injury are warranted.
Databáze:	OpenAIRE
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