A Handheld, Colorimetric Optoelectronic Dynamics Analyzer for Measuring Total Ammonia of Biological Samples
| Autor: | Tianmiao Lai, Erica Forzani, Mark Sprowls, Leslie Thomas, Pinar Cay-Durgun, Mary Laura Lind, Nai-Yuan Liu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medical diagnosis
Spectrum analyzer lcsh:Medical technology Biomedical Engineering Ammonia levels 02 engineering and technology Urine lcsh:Computer applications to medicine. Medical informatics 01 natural sciences Article chemistry.chemical_compound Ammonia Ammonium Rapid response Chromatography 010401 analytical chemistry chemical sensors General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Biosensors clinical diagnosis lcsh:R855-855.5 chemistry Urine anion gap optoelectronic devices lcsh:R858-859.7 0210 nano-technology Biosensor |
| Zdroj: | IEEE Journal of Translational Engineering in Health and Medicine IEEE Journal of Translational Engineering in Health and Medicine, Vol 6, Pp 1-10 (2018) |
| ISSN: | 2168-2372 |
| Popis: | This paper introduces a wireless, solid-state, portable, and automated device capable of measuring the total ammonia [ammonia (NH3) and ammonium (NH4+)] levels of fluids, including biological samples. This device reliably measures the total ammonia of biological samples (e.g., urine) faster than the current ammonia quantification techniques. Medical professionals typically estimate NH4+ levels using error-prone indirect measurement techniques (i.e., urine anion gap), which are time-consuming and are seldom suitable for periodic measurements. Several instantaneous measurements of total ammonia levels in a patient urine could be utilized as an early warning for both acid-base and/or potassium disturbances. Given the device’s operation mechanism, it is able to quantify the total ammonia concentration within a biological sample in only 5 s and can simultaneously transmit data to other devices via Bluetooth. The analytical operation demonstrated high sensitivity, high specificity, fast reversibility, rapid response time, and has enabled the accurate determination of total ammonia concentration in urine samples produced by subjects who had consumed diets of variable protein compositions. The handheld device could semi-continuously measure the total ammonia level in urine samples as a diagnostic device to provide early physiological unbalance warnings. |
| Databáze: | OpenAIRE |
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