Pseudoglandular schwannoma of the cauda equina
| Autor: | Leonardo De Cerchio, Arianna Bakacs, Pierpaolo Lunardi, Francesco Ruggeri, Augusto Orlandi |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty peripheral nerve sheath tumor glandular schwannoma pseudoglandular schwannoma divergent differentiation Cauda Equina Settore MED/08 - Anatomia Patologica Schwannoma S100 protein Epithelium Peripheral Nervous System Neoplasms otorhinolaryngologic diseases Humans Medicine Antoni B Pattern Metaplasia business.industry S100 Proteins Cauda equina General Medicine Anatomy medicine.disease Immunohistochemistry Tissue sections medicine.anatomical_structure Epithelial Metaplasia Keratins Schwann Cells Epithelial Membrane Antigen business Neurilemmoma |
| Zdroj: | Journal of Neurosurgery: Spine. 5:543-545 |
| ISSN: | 1547-5654 |
| Popis: | ✓The authors present a case of pseudoglandular schwannoma with immunohistochemical findings consistent with epithelial metaplasia. Pseudoglandular schwannoma is a rare morphological variant of benign schwannoma characterized by the presence of glandlike structures lined with Schwann cells. To the best of the authors’ knowledge, this is only the fifth case of pseudoglandular schwannoma reported in the literature. Clinical, imaging, and pathological findings are described. The pathological findings were consistent with a pseudoglandular schwannoma composed of typical Schwann cells arranged in an Antoni B pattern, with numerous large pseudocystic spaces. Serial immunohistochemical studies of tissue sections revealed that the cells lining the pseudoglandular spaces were not only diffusely reactive for S100 protein, but also demonstrated focal positivity for epithelial membrane antigen and cytokeratins AE1 and AE3. The particular immunohistochemical features of incompletely differentiated Schwann cells in the present case give support to the metaplastic theory of the origin of glandlike structures in benign peripheral nerve sheath tumors. |
| Databáze: | OpenAIRE |
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