Factors predicting poor anticoagulant control on warfarin in a Thai population with non-valvular atrial fibrillation (NVAF): the ACAChE score

Autor: Anurut Huntrakul, Somchai Prechawat, Ronpichai Chokesuwattanaskul, Piyoros Lertsanguansinchai, Voravut Rungpradubvong
Rok vydání: 2021
Předmět:
Zdroj: International Journal of Arrhythmia, Vol 22, Iss 1, Pp 1-11 (2021)
ISSN: 2466-1171
DOI: 10.1186/s42444-021-00038-8
Popis: Background In many low- to middle-income countries in Asia, patients with NVAF usually received warfarin for thromboembolic prevention due to cost-effectiveness. The SAMe-TT2R2 score has been proposed to predict TTR in NVAF patients. However, the SAMe-TT2R2 score has not been much validated in Asian population. Interestingly, it may overestimate patients who had TTR Objectives To determine the factors predicting poor anticoagulant control on warfarin, create new scoring system, and compare with the SAMe-TT2R2 score in a Thai population with NVAF. Methods This is a retrospective study in a tertiary care hospital. We enrolled NVAF patients who received warfarin from January 2014 to December 2018. TTR was calculated based on Rosendaal method. Multiple logistic regression and AUC-ROC curve were used for analysis. Results A total of 864 patients were enrolled with mean age of 73.6 ± 11.58 years. The mean TTR was 48.1 ± 25.2%. Using multivariate regression analysis, the predictive factors for TTR p ≤ 0.001), LVEF p = 0.037), chronic kidney disease (GFR 2) (OR 1.68, p = 0.013), history of CHF (OR 1.7, p = 0.047), and age ≥ 75 years (OR 1.4, p = 0.037). Based on the regression coefficients, we developed the new scoring system called ACAChE score [A, antiplatelet use (4 points); C, chronic kidney disease, GFR 2 (2 points); A, age ≥ 75 years (1 point); Ch, history of CHF (2 points); E, LVEF Conclusion In Thai NVAF patients, the ACAChE score (antiplatelet use, chronic kidney disease (GFR 2), age ≥ 75 years, history of congestive heart failure, and LVEF
Databáze: OpenAIRE
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