Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons
| Autor: | Yingtang Shi, Roman M. Lazarenko, Douglas A. Bayliss, Jorge Soliz, Ana Velic, Patrice G. Guyenet, Janelle L. Weaver, Max Gassmann, Klaus Seuwen, Nilufar Mohebbi, Carsten A. Wagner, Edward Perez-Reyes, Thomas Suply, Natasha N. Kumar, Josh Sen, Marie-Gabrielle Ludwig, Stephen B. G. Abbott, Sheng Wang, Carla Bettoni, Ke-Yong Li |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Biology Article Homeostatic Process Receptors G-Protein-Coupled Mice Potassium Channels Tandem Pore Domain Respiration medicine Animals Trapezoid body Respiratory system Receptor Trapezoid Body Neurons Mice Inbred BALB C Multidisciplinary Apnea Anatomy Carbon Dioxide Phenotype Mice Mutant Strains Cell biology Mice Inbred C57BL Breathing Female Acidosis Respiratory medicine.symptom Gene Deletion |
| Zdroj: | SCIENCE |
| DOI: | 10.1126/science.aaa0922 |
| Popis: | Receptor in the brain controls breathing Control of breathing in mammals depends primarily not on sensing oxygen, but rather on detecting concentrations of carbon dioxide in the blood. Failure of this system can cause potentially deadly sleep apnias. Taking a hint from insects, which use a heterotrimeric guanine nucleotide–binding protein-coupled receptor (GPCR) to sense carbon dioxide, Kumar et al. demonstrate that the GPCR GPR4 is essential to control breathing in mice. GPR4 senses protons generated by the formation of carbonic acid in the blood and works with a pH-sensitive potassium channel called TASK-2 in a set of brain cells that control breathing. Science , this issue p. 1255 |
| Databáze: | OpenAIRE |
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