Intravenous pamidronate in combination with calcium and vitamin D: highly effective in the treatment of low bone mineral density in inflammatory bowel disease
| Autor: | Sander J. H. van Deventer, Hein J. Verberne, Mirjam van der Spek, Pieter C. F. Stokkers, Daniel W. Hommes, Maartje Deley |
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| Přispěvatelé: | Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Gastroenterology and Hepatology, Other departments, Amsterdam Cardiovascular Sciences, Nuclear Medicine, 01 Internal and external specialisms |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Bone density Osteoporosis Pamidronate Gastroenterology Absorptiometry Photon Bone Density Internal medicine Vitamin D and neurology medicine Humans Vitamin D Infusions Intravenous Bone mineral Crohn's disease Lumbar Vertebrae Bone Density Conservation Agents Diphosphonates business.industry Femur Neck Pamidronic acid medicine.disease Inflammatory Bowel Diseases Surgery Osteopenia Treatment Outcome Tolerability Calcium Drug Therapy Combination Female business medicine.drug Follow-Up Studies |
| Zdroj: | Scandinavian journal of gastroenterology, 41(2), 200-204. Informa Healthcare |
| ISSN: | 0036-5521 |
| DOI: | 10.1080/00365520500206467 |
| Popis: | OBJECTIVE: Decreased bone mineral density (BMD) is common in inflammatory bowel disease (IBD) and an increased risk of fractures has been reported. Guidelines state bisphosphonate treatment for IBD patients with decreased BMD, but orally available bisphosphonates have been associated with gastrointestinal side effects and the absorption is poor. We investigated whether intravenous pamidronate is a safe and effective treatment. MATERIAL AND METHODS: Forty-nine IBD patients with decreased BMD as assessed by DEXA scan were treated with calcium 1000 mg and vitamin D 400 IU daily. In addition, 30 mg of pamidronate was administered intravenously every 3 months. DEXA scanning was performed prior to treatment, after 6 months and after 1 year. RESULTS: Of 49 IBD patients, 40 were osteoporotic and 9 were osteopenic. Twenty-six patients were female (mean age 40.8) and 23 were male (mean age 43.3). Treatment was discontinued in one patient because of fever after infusion. Otherwise, tolerability was excellent, and no adverse events were documented. A mean 0.51 increase of lumbar spine (L1-L4) T-scores was observed (CI 95% 0.35-0.67; p |
| Databáze: | OpenAIRE |
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