A novel compartmentalised stent graft to isolate the perfusion of the abdominal organs
| Autor: | Bryan W. Tillman, Yanfei Chen, Tara D. Richards, Amit D. Tevar, Xinzhu Gu, William R. Wagner, Youngjae Chun, Sung Kwon Cho |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Swine medicine.medical_treatment Device placement Biomedical Engineering Ischemia Transplants Economic shortage Pilot Projects 030230 surgery Models Biological 03 medical and health sciences 0302 clinical medicine medicine Animals Humans business.industry Open surgery Stent Donation after cardiac death General Medicine Blood flow medicine.disease Tissue Donors Surgery Perfusion Hydrodynamics Feasibility Studies 030211 gastroenterology & hepatology Female Stents business |
| Zdroj: | Journal of medical engineeringtechnology. 41(2) |
| ISSN: | 1464-522X |
| Popis: | Donation after cardiac death has been adopted to address the critical shortage of donor organs for transplant. Recovery of these organs is hindered by low blood flow that leads to permanent organ injury. We propose a novel approach to isolate the perfusion of the abdominal organs from the systemic malperfusion of the dying donor. We reasoned that this design could improve blood flow to organs without open surgery, while respecting the ethical principle that cardiac stress not be increased during organ recovery. Conditions within the stent were analysed using a computational fluid dynamics (CFD) method and validated on two prototypes in vitro. The hydrodynamic pressure drop across the stent was measured as 0.14-0.22 mmHg, which is a negligible influence. Device placement studies were also conducted on swine model fluoroscopically. All these results demonstrated the feasibility of rapidly isolating the perfusion to abdominal organs using a compartmentalised stent graft design. |
| Databáze: | OpenAIRE |
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