Design and Synthesis of Novel 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Cyclooxygenase-2 Inhibitors with Anti-inflammatory and Antioxidant activity in LPS-stimulated RAW264.7 Macrophages
| Autor: | Mohamed M.S. Hamoud, Nermine A. Osman, Samar Rezq, Hend A. A. Abd El-wahab, Abdalla E. A. Hassan, Hanan A. Abdel-Fattah, Damian G. Romero, Amany M. Ghanim |
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| Rok vydání: | 2021 |
| Předmět: |
Lipopolysaccharides
Oxadiazoles Cyclooxygenase 2 Inhibitors Interleukin-6 Macrophages Organic Chemistry Anti-Inflammatory Agents Non-Steroidal Anti-Inflammatory Agents Triazoles Nitric Oxide Biochemistry Antioxidants Molecular Docking Simulation Structure-Activity Relationship Celecoxib Cyclooxygenase 2 Drug Design Drug Discovery Reactive Oxygen Species Molecular Biology |
| Zdroj: | Bioorganic chemistry. 124 |
| ISSN: | 1090-2120 |
| Popis: | In an attempt to obtain new candidates with potential anti-inflammatory activity, two series of 1,3,4-oxadiazole based derivatives (8a-g) and 1,2,4-triazole based derivatives (10a,b and 11a-g) were synthesized and evaluated for their COX-1/COX-2 inhibitory activity. In vitro assays showed potent COX-2 inhibitory activity and selectivity of the novel designed compounds (IC |
| Databáze: | OpenAIRE |
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