AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice
| Autor: | Kristof Schutters, Chris P. M. Reutelingsperger, Dennis H. M. Kusters, Emiel P. C. van der Vorst, Mauro Perretti, Lucy V. Norling, Brecht A. G. Willems, Erik A.L. Biessen, Leon J. Schurgers, Jack P.M. Cleutjens, Mathias Burgmaier, Martijn L. Chatrou |
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| Přispěvatelé: | RS: CARIM - R1 - Thrombosis and haemostasis, RS: CARIM - R3 - Vascular biology, Promovendi CD, Pathologie, Biochemie, Genetica & Celbiologie |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty phosphatidylserine Blotting Western Inflammation Biology Peripheral blood mononuclear cell Lesion Immunoenzyme Techniques chemistry.chemical_compound Mice Apolipoproteins E medicine Cell Adhesion Macrophage Animals Cells Cultured Mice Knockout Macrophages apoptosis annexin A5 Cell Biology Phosphatidylserine Original Articles Flow Cytometry Plaque Atherosclerotic Endothelial stem cell Disease Models Animal chemistry plaque inflammation Apoptosis Molecular Medicine medicine.symptom Annexin A5 atherosclerosis |
| Zdroj: | Journal of Cellular and Molecular Medicine, 18(10), 2117-2124. Wiley-Blackwell Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-1838 |
| Popis: | Annexin A5 (AnxA5) exerts anti-inflammatory, anticoagulant and anti-apoptotic effects through binding cell surface expressed phosphatidylserine. The actions of AnxA5 on atherosclerosis are incompletely understood. We investigated effects of exogenous AnxA5 on plaque morphology and phenotype of advanced atherosclerotic lesions in apoE−/− mice. Advanced atherosclerotic lesions were induced in 12 weeks old Western type diet fed apoE−/− mice using a collar placement around the carotid artery. After 5 weeks mice were injected either with AnxA5 (n = 8) or vehicle for another 4 weeks. AnxA5 reduced plaque macrophage content both in the intima (59% reduction, P |
| Databáze: | OpenAIRE |
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