| Autor: |
Nandini Nair, Shengping Yang, Caroline Marzbani, Aiswarya J. Pillai, Veena Agusala, Tatiana Denega, Pakpoom Tantrachoti, Enrique Gongora |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Acta cardiologica. |
| ISSN: |
1784-973X |
| Popis: |
Abnormalities in coagulation and inflammation exist in heart failure. This study compares the diagnostic accuracy of NT-proBNP and D-Dimer and the correlation of these biomarkers with echocardiographic parameters in acute decompensated heart failure.A retrospective cross-sectional/observational study was performed using 162 patients with acute decompensated heart failure and 253 age-matched controls. Patients were ruled out for a pulmonary embolus by CT or VQ scans. The study protocol was approved by Institutional Review Board, Lubbock, TX. Correlation of NT-proBNP and D-Dimer values was done with echocardiographic parameters. Statistical significance was assumed atD-Dimer showed a positive correlation with NT-proBNP (Comparison of the AUC values for D-Dimer versus the combination of D-Dimer and NT-proBNP showed no significance suggestive of comparable diagnostic accuracy in the study population. The lack of correlation between D-Dimer and echocardiographic parameters suggests an independent pathophysiological mechanism underlying upregulation of D-Dimer in acute decompensated heart failure. Further systematic studies are needed to define mechanism of D-Dimer increase in heart failure. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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