Kidney organoid systems for studies of immune-mediated kidney diseases: challenges and opportunities
| Autor: | Melissa C. Stein, Christian Krebs, Madeleine J. Bunders, Fabian Braun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Histology 030232 urology & nephrology Inflammation Review Bioinformatics Pathology and Forensic Medicine Pathogenesis Immune cell–epithelial cell interaction 03 medical and health sciences 0302 clinical medicine Immune system medicine Organoid Animals Humans Kidney business.industry Regeneration (biology) Kidney organoids Immune cells Immune-mediated kidney diseases Cell Biology Human genetics Organoids Multicellular organism 030104 developmental biology medicine.anatomical_structure Tubuloids Kidney Diseases medicine.symptom business |
| Zdroj: | Cell and Tissue Research |
| ISSN: | 1432-0878 0302-766X |
| Popis: | Acute and chronic kidney diseases are major contributors to morbidity and mortality in the global population. Many nephropathies are considered to be immune-mediated with dysregulated immune responses playing an important role in the pathogenesis. At present, targeted approaches for many kidney diseases are still lacking, as the underlying mechanisms remain insufficiently understood. With the recent development of organoids—a three-dimensional, multicellular culture system, which recapitulates important aspects of human tissues—new opportunities to investigate interactions between renal cells and immune cells in the pathogenesis of kidney diseases arise. To date, kidney organoid systems, which reflect the structure and closer resemble critical aspects of the organ, have been established. Here, we highlight the recent advances in the development of kidney organoid models, including pluripotent stem cell-derived kidney organoids and primary epithelial cell-based tubuloids. The employment and further required advances of current organoid models are discussed to investigate the role of the immune system in renal tissue development, regeneration, and inflammation to identify targets for the development of novel therapeutic approaches of immune-mediated kidney diseases. |
| Databáze: | OpenAIRE |
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