Diffuse Gastric Carcinoma Undergoes Characteristic Phenotypic Changes in the Intravascular Environment: Evidence for a Reversal of the Epithelial-Mesenchymal Transition in Lymphovascular Metastasis
| Autor: | Tim Bracey, Louise C. Keers, Mark E F Smith, Susan A. Adams |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Epithelial-Mesenchymal Transition Adenocarcinoma Biology Pathology and Forensic Medicine Metastasis 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Biomarkers Tumor Cell Adhesion medicine Carcinoma Humans Neoplasm Invasiveness Epithelial–mesenchymal transition Lymph node Cadherin Cadherins medicine.disease Immunohistochemistry Lymphovascular Phenotype 030104 developmental biology medicine.anatomical_structure Lymphatic Metastasis 030220 oncology & carcinogenesis Catenin Surgery Anatomy |
| Zdroj: | International Journal of Surgical Pathology. 25:222-229 |
| ISSN: | 1940-2465 1066-8969 |
| Popis: | This article reports differences between the properties of extravascular carcinoma, which generally forms the vast bulk of a tumor, and those of intravascular carcinoma, at both primary and metastatic lymph node sites. In a morphological and immunohistochemical study of 19 diffuse gastric adenocarcinomas, we report that in comparison to extravascular carcinoma, the intravascular tumor compartment showed frequent and profound phenotypic change, including increased tumor cell cohesion, differentiation and cadherin/catenin expression. For example, greatest cohesion was seen at the intravascular site in 78% ( P = .00006) of primary cancers and in 84% ( P = .000015) of their lymph node metastases. Pan cadherin showed a statistically significant increase at the intravascular metastatic site ( P = .031). We suggest that this change from an extravascular isolated cell phenotype to an intravascular cohesive phenotype represents reversal of the epithelial to mesenchymal transition. Since this proposed reversal of epithelial to mesenchymal transition in intravascular carcinoma is frequently conspicuous in routine histological sections of many types of cancer, as our previous publications have indicated, this process is likely to have widespread significance for the biology of metastasis. |
| Databáze: | OpenAIRE |
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