Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
| Autor: | Nandini Nandeesha, Jelena Popov, Nikhil Pai, David Avelar Rodriguez, Valentina Caputi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
pediatrics
Colorectal cancer QH301-705.5 colorectal cancer Review Disease Inflammatory bowel disease inflammatory bowel diseases antibiotics fecal microbiota transplant Catalysis Inorganic Chemistry Pathogenesis Immune system medicine CAC Animals Humans Physical and Theoretical Chemistry synbiotics Biology (General) Molecular Biology QD1-999 Spectroscopy ulcerative colitis FMT business.industry Microbiota Organic Chemistry Cancer dysbiosis General Medicine medicine.disease Ulcerative colitis CRC Computer Science Applications Chemistry probiotics colitis-associated cancer Host-Pathogen Interactions Immunology Colitis Ulcerative Colitis-Associated Neoplasms prebiotics business Dysbiosis |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 11365, p 11365 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic and environmental factors is suspected. Research has focused on the role of intestinal dysbiosis in the pathogenesis of UC, including the effects of dysbiosis on the integrity of the colonic mucosal barrier, priming and regulation of the host immune system, chronic inflammation, and progression to tumorigenesis. Characterization of key microbial taxa and their implications in the pathogenesis of UC and colitis-associated cancer (CAC) may present opportunities for modulating intestinal inflammation through microbial-targeted therapies. In this review, we discuss the microbiota-immune crosstalk in UC and CAC, as well as the evolution of microbiota-based therapies. |
| Databáze: | OpenAIRE |
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