Acromegaly presenting with low insulin-like growth factor-1 levels and diabetes: a case report
| Autor: | Dishni Wijesundera, Maulee Hiromi Arambewela, Dilushi Rowena Wijayaratne, Chamara Dalugama, Noel Somasundaram, Prasad Katulanda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pituitary gland
medicine.medical_specialty medicine.medical_treatment Case Report Pituitary neoplasm Surgical oncology Diabetes mellitus Internal medicine Acromegaly medicine Endocrine system Humans Pituitary Neoplasms Insulin-Like Growth Factor I Medicine(all) Aged 80 and over business.industry Human Growth Hormone Growth factor Diabetes General Medicine medicine.disease Magnetic Resonance Imaging Growth hormone secretion medicine.anatomical_structure Endocrinology Insulin-like growth factor-1 Diabetes Mellitus Type 2 Pituitary Gland Female business |
| Zdroj: | Journal of Medical Case Reports |
| ISSN: | 1752-1947 |
| Popis: | Introduction Acromegaly is an endocrine disorder arising from excessive serum growth hormone levels in adulthood and is characterized by progressive somatic enlargement. Biochemical confirmation is achieved by demonstration of elevated baseline serum growth hormone levels which are not suppressed during an oral glucose tolerance test, and by increased levels of serum insulin-like growth factor-1. The serum insulin-like growth factor-1 level provides an assessment of integrated growth hormone secretion and is recommended for diagnosis, monitoring, and screening of acromegaly. We report a case of a patient with acromegaly secondary to a pituitary microadenoma who presented with low insulin-like growth factor-1. Case presentation An 83-year-old Sinhalese woman presented to our hospital with an enlarging multinodular goiter. She was observed to have macroglossia, thickened coarse skin, acral enlargement, and newly detected, uncontrolled diabetes. A diagnosis of acromegaly was suspected. She did not complain of recent headaches, vomiting, visual difficulties, or galactorrhea and was clinically euthyroid. Her pulse rate was 84 beats/min, and her blood pressure was 150/90 mmHg. A visual field assessment did not reveal a defect. Her random growth hormone levels were 149 mU/L ( |
| Databáze: | OpenAIRE |
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