Effects of Rabeprazole, a Gastric Proton Pump Inhibitor, on Biliary and Hepatic Lysosomal Enzymes in Rats
| Autor: | Osamu Takenaka, Yoshiharu Yamanishi, Kiyoshi Oketani, Junichi Nagakawa, Hideaki Fujisaki |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Rabeprazole Pharmacology Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Rats Sprague-Dawley Chloroquine Internal medicine Acetylglucosaminidase Gastric mucosa medicine Animals Bile Enzyme Inhibitors Omeprazole Bile acid biology Chemistry Bile duct Proton Pump Inhibitors beta-Galactosidase Lipids Enzyme assay Rats Proton pump medicine.anatomical_structure Liver Gastric Mucosa biology.protein Benzimidazoles Lysosomes medicine.drug |
| Zdroj: | Japanese Journal of Pharmacology. 76:279-288 |
| ISSN: | 0021-5198 |
| DOI: | 10.1254/jjp.76.279 |
| Popis: | The effects of rabeprazole (E3810), omeprazole and chloroquine on hepatic lysosomal function were studied. After chloroquine (50 mg/kg), rabeprazole (5 mg/kg) or omeprazole (5 mg/kg) was given intraperitoneally to rats for 6 days, the bile was collected via a bile duct cannula for 5 hr, and hepatic and biliary lysosomal enzyme (N-acetyl-beta-glucosaminidase and beta-galactosidase) activities were measured. The latency (an index for the hepatic lysosomal membrane integrity) was calculated from the N-acetyl-beta-glucosaminidase activity. The biliary constituents and plasma concentrations of lipids were also measured. The administration of chloroquine significantly increased hepatic and biliary lysosomal enzyme activities, but did not affect the lysosomal enzyme latency, hepatic and biliary protein content or bile flow. It significantly decreased the bile acid level. On the other hand, the administration of rabeprazole and omeprazole did not alter the lysosomal enzyme activities, lysosomal enzyme latency, protein content in liver or liver weight. Furthermore, no significant differences were observed in biliary lysosomal enzyme activity, protein content, bile flow, biliary constituents or in the plasma concentrations of lipids between the drug groups (rabeprazole or omeprazole) and the control group. The results of the present study indicate that rabeprazole, like omeprazole, does not influence hepatic lysosomal function. |
| Databáze: | OpenAIRE |
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