Biologically Responsive Plasmonic Assemblies for Second Near-Infrared Window Photoacoustic Imaging-Guided Concurrent Chemo-Immunotherapy
| Autor: | Zhan-Wei Li, Jiayong Dai, Xiaoyuan Chen, Jibin Song, Lichao Su, Rong Zhu, Shumeng Bai, Huanghao Yang, Qingqing Li |
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| Rok vydání: | 2020 |
| Předmět: |
Polymers
General Physics and Astronomy Photoacoustic imaging in biomedicine Nanoparticle Metal Nanoparticles 02 engineering and technology 010402 general chemistry 01 natural sciences Photoacoustic Techniques chemistry.chemical_compound PEG ratio General Materials Science Plasmon Chemo immunotherapy Chemistry Vesicle technology industry and agriculture General Engineering 021001 nanoscience & nanotechnology 0104 chemical sciences Colloidal gold Biophysics Nanoparticles Gold Immunotherapy 0210 nano-technology Ethylene glycol |
| Zdroj: | ACS nano. 14(4) |
| ISSN: | 1936-086X |
| Popis: | We developed dual biologically responsive nanogapped gold nanoparticle vesicles loaded with immune inhibitor and carrying an anticancer polymeric prodrug for synergistic concurrent chemo-immunotherapy against primary and metastatic tumors, along with guided cargo release by photoacoustic (PA) imaging in the second near-infrared (NIR-II) window. The responsive vesicle was prepared by self-assembly of nanogapped gold nanoparticles (AuNNPs) grafted with poly(ethylene glycol) (PEG) and dual pH/GSH-responsive polyprodug poly(SN38-co-4-vinylpyridine) (termed AuNNP@PEG/PSN38VP), showing intense PA signal in the NIR-II window. The effect of the rigidity of hydrophobic polymer PSN38VP on the assembled structures and the formation mechanism of AuNNP@SN38 Ve were elucidated by computational simulations. The immune inhibitor BLZ-945 was encapsulated into the vesicles, resulting in pH-responsive release of BLZ-945 for targeted immunotherapy, followed by the dissociation of the vesicles into single AuNNP@PEG/PSN38VP. The hydrophilic AuNNP@PEG/PSN38VP nanoparticles could penetrate deep into the tumor tissues and release the anticancer drug SN38 under the reductive environment. A PA signal in the NIR-II window in the deep tumor region was obtained. The BLZ-945-loaded vesicle enabled enhanced PA imaging-guided concurrent chemo-immunotherapy efficacy, inhibiting the growth of both primary tumors and metastatic tumors. |
| Databáze: | OpenAIRE |
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