Association between Urinary Phytoestrogens and C-reactive Protein in the Continuous National Health and Nutrition Examination Survey
| Autor: | Ziyue Liu, Terrell W. Zollinger, Jianjun Zhang, Michael K. Reger, Josette Jones |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty National Health and Nutrition Examination Survey Urinary system Medicine (miscellaneous) Physiology Phytoestrogens 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Enterolactone Interquartile range Internal medicine medicine Humans Aged Nutrition and Dietetics biology C-reactive protein food and beverages Middle Aged Nutrition Surveys Confidence interval United States Endocrinology C-Reactive Protein Logistic Models chemistry 030220 oncology & carcinogenesis biology.protein Biomarker (medicine) Female |
| Zdroj: | Journal of the American College of Nutrition. 36(6) |
| ISSN: | 1541-1087 |
| Popis: | A reduced risk of some cancers and cardiovascular disease associated with phytoestrogen intake may be mediated through its effect on serum C-reactive protein (CRP; an inflammation biomarker). Therefore, this study examined the associations between urinary phytoestrogens and serum CRP.Urinary phytoestrogen and serum CRP data obtained from 6009 participants aged ≥ 40 years in the continuous National Health and Nutrition Examination Survey during 1999-2010 were analyzed.After adjustment for confounders, urinary concentrations of total and all individual phytoestrogens were inversely associated with serum concentrations of CRP (all p0.004). The largest reductions in serum CRP (mg/L) per interquartile range increase in urinary phytoestrogens (ng/mL) were observed for total phytoestrogens (β = -0.18; 95% confidence interval [CI], -0.22, -0.15), total lignan (β = -0.15; 95% CI, -0.18, -0.12), and enterolactone (β = -0.15; 95% CI, -0.19, -0.12). A decreased risk of having high CRP concentrations (≥3.0 mg/L) for quartile 4 vs quartile 1 was also found for total phytoestrogens (OR = 0.63; 95% CI, 0.53, 0.73), total lignan (OR = 0.64; 95% CI, 0.54, 0.75), and enterolactone (OR = 0.59; 95% CI, 0.51, 0.69).Urinary total and individual phytoestrogens were significantly inversely associated with serum CRP in a nationally representative sample of the U.S. |
| Databáze: | OpenAIRE |
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