Creutzfeldt-Jakob disease: a case with extensive white matter degeneration and optic atrophy
| Autor: | T. Ishii, Atsuo Koto, Fumio Gotoh, Hiroyuki Okayasu, Yasuhisa Kitagawa, Shinichiro Ebihara, Haruo Matsuyama |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
medicine.medical_specialty
Pathology Neurology Disease Degeneration (medical) Cerebellar white matter Creutzfeldt-Jakob Syndrome White matter Atrophy White matter degeneration mental disorders Medicine Humans Neuroradiology business.industry Brain Middle Aged medicine.disease nervous system diseases Optic Atrophy medicine.anatomical_structure Female Neurology (clinical) business Tomography X-Ray Computed |
| Zdroj: | Journal of neurology. 229(2) |
| ISSN: | 0340-5354 |
| Popis: | A 52-year-old woman is described, whose clinical features were typical of Creutzfeldt-Jakob disease except for the presence of optic atrophy. Serial CT scans showed rapid development of brain atrophy early in the course. Postmortem examination revealed extensive degeneration of the cerebral and cerebellar white matter and of the optic nerves in addition to the classic findings of Creutzfeldt-Jakob disease. It is suggested that both the grey and white matter may undergo a severe destructive process early in the course of the disease, and the possibility is discussed that the white matter involvement is not a result of neuronal loss. |
| Databáze: | OpenAIRE |
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