Decreased B Cells on Admission Associated With Prolonged Viral RNA Shedding From the Respiratory Tract in Coronavirus Disease 2019: A Case-Control Study

Autor: Shaorui Hao, Shufa Zheng, Jifang Sheng, Tingbo Liang, Dairong Xiang, Liang Yu, Xiaopeng Yu, Yingfeng Lu, Hong Zhao, Yida Yang, Jianhua Hu, Qin Ni, Xiaoyan Wang, Xuan Zhang, Yongtao Li, Kaijin Xu, Jiangshan Lian, Lanjuan Li, Guodong Yu, Jun Liu, Yu Chen, Yunqing Qiu, Hongyu Jia
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Time Factors
Respiratory System
Gastroenterology
0302 clinical medicine
Risk Factors
Interquartile range
Immunology and Allergy
030212 general & internal medicine
Respiratory system
B-Lymphocytes
biology
Brief Report
Middle Aged
Virus Shedding
AcademicSubjects/MED00290
Infectious Diseases
medicine.anatomical_structure
Real-time polymerase chain reaction
Quartile
IL-10
Cytokines
RNA
Viral

Female
Coronavirus Infections
viral RNA shedding
China
medicine.medical_specialty
Pneumonia
Viral

T cells
Real-Time Polymerase Chain Reaction
Betacoronavirus
03 medical and health sciences
Internal medicine
medicine
Humans
AcademicSubjects/MED00860
Lymphocyte Count
Viral shedding
Pandemics
Proportional Hazards Models
Retrospective Studies
B cells
SARS-CoV-2
business.industry
Case-control study
COVID-19
biology.organism_classification
Logistic Models
030104 developmental biology
Case-Control Studies
business
Respiratory tract
Zdroj: The Journal of Infectious Diseases
ISSN: 1537-6613
0022-1899
DOI: 10.1093/infdis/jiaa311
Popis: The viral RNA shedding time (VST) for severe acute respiratory syndrome coronavirus 2 has not been well characterized. Clinical data were collected and compared between patients with short and long VSTs (in the lower and upper quartiles, respectively). The probability of recurrent positive reverse-transcription polymerase chain reaction results decreased sharply to 4.8% after 3 consecutive negative results. A series of ≥3 consecutive negative results was suitable as a criterion for the end of viral RNA shedding. The VST for shedding from the respiratory tract was significantly shorter in patients with normal B-cell counts on admission than in those with decreased B-cell counts (median [interquartile range], 11 [9–13] vs 16 [12–20] days, respectively; P = .001).
Databáze: OpenAIRE