THE EFFECT OF SIMULATED BIRTH TRAUMA AND/OR OVARIECTOMY ON RODENT CONTINENCE MECHANISM. PART I: FUNCTIONAL AND STRUCTURAL CHANGE

Autor:	Karl-Dietrich Sievert, S. E. Dahms, Tony Tsai, Lora Nunes, Mustafa Emre Bakircioglu, Tom F. Lue
Rok vydání:	2001
Předmět:	medicine.medical_specialty Sneeze medicine.diagnostic_test business.industry Birth trauma Urology Urinary system Cystometry Urinary incontinence medicine.disease Surgery Neck of urinary bladder Urethra medicine.anatomical_structure Balloon dilation medicine medicine.symptom business
Zdroj:	Journal of Urology. 166:311-317
ISSN:	1527-3792 0022-5347
DOI:	10.1016/s0022-5347(05)66151-4
Popis:	Purpose: We examined the changes in the lower urinary tract after delivery, intravaginal ballooning and/or ovariectomy.Materials and Methods: The study included 10 virgin and 48 primiparous pregnant rats. Cystometry and the stress/sneeze test were performed in virgin and postpartum rats shortly after delivery and at 8 weeks before sacrifice. Half of the delivered animals underwent intravaginal balloon dilation. Four weeks later half in each group underwent ovariectomy. The rats were subdivided into group 1—delivery, group 2—delivery plus balloon inflation, group 3—delivery plus ovariectomy and group 4—delivery plus balloon inflation plus ovariectomy. Tissues from the bladder, bladder neck, urethra and levator were collected, analyzed by electron microscopy, and immunostained for caveolin-1, caveolin-3 and neuronal nitric oxide synthase.Results: Higher bladder capacity was detected in postpartum than in virgin rats. Urine leakage on stress/sneeze testing increased significantly in groups 2 and 4. Electron ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641e004932536de24dc1a566a0624778 https://doi.org/10.1016/s0022-5347(05)66151-4 Zobrazit plný text záznamu