Circulating fibrocytes are not disease-specific prognosticators in idiopathic pulmonary fibrosis
| Autor: | Martin Kolb, Shyam Maharaj, Grazziela P. Figueredo, Kjetil Ask, Henry Nanji, William A. Fahy, Toby M. Maher, Antje Ask, Gisli Jenkins, Iain A. Stewart |
|---|---|
| Přispěvatelé: | National Institute for Health Research, British Lung Foundation |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry Hazard ratio Respiratory System Disease Fibroblasts medicine.disease Gastroenterology Fibrosis Research Letters Idiopathic Pulmonary Fibrosis Idiopathic pulmonary fibrosis Internal medicine Pulmonary fibrosis Cohort Fibrocyte medicine Risk of mortality Humans Observational study business Agora 11 Medical and Health Sciences |
| Zdroj: | The European Respiratory Journal article-version (VoR) Version of Record |
| ISSN: | 1399-3003 0903-1936 |
| Popis: | A number of previous studies have observed greater levels of circulating fibrocytes in interstitial lung disease compared to healthy controls, and suggest a prognostic role in idiopathic pulmonary fibrosis (IPF) [1–4]. Fibrocytes are circulating mesenchymal progenitor cells that differentiate into tissue specific fibroblasts and contribute to multiple wound healing processes, including secretion of inflammatory cytokines, contractile wound closure and promotion of angiogenesis [5]. However, the contribution of fibrocytes to the pathogenesis of progressive pulmonary fibrosis remains unclear and clinical observations require independent validation in prospective cohorts. In people with idiopathic pulmonary fibrosis, circulating fibrocytes ≥2.2% were associated with a greater risk of mortality over a median 3 years of follow-up, but were not associated with disease-related decline in lung function or short-term progression. https://bit.ly/3bWydwQ |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|